After building and running Cesium for Unreal demo (v. 4.27), which works OK, noted these lines in the UE4 output log:
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: invalid HTTP response code received. URL: https://assets.cesium.com/1/6/24/42.terrain?v=1.2.0&extensions=octvertexnormals-metadata, HTTP code: 0, content length: 0, actual payload size: 0
LogPlayLevel: Error: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: request failed, libcurl error: 35 (SSL connect error)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 0 (Found bundle for host assets.cesium.com: 0x2123e80a5d0 [can pipeline])
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 1 (Hostname assets.cesium.com was found in DNS cache)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 2 ( Trying 13.249.109.85...)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 3 (TCP_NODELAY set)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 4 (Connected to assets.cesium.com (13.249.109.85) port 443 (#1654))
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 5 (ALPN, offering http/1.1)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 6 (Cipher selection: ALL:!EXPORT:!EXPORT40:!EXPORT56:!aNULL:!LOW:!RC4:@STRENGTH)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 7 (SSL re-using session ID)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 8 (TLSv1.3 (OUT), TLS handshake, Client hello (1):)
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 9 (OpenSSL SSL_connect: SSL_ERROR_SYSCALL in connection to assets.cesium.com:443 )
LogPlayLevel: Warning: [2021.10.12-17.42.01:839][855]LogHttp: Warning: 000002128C9BA4C0: libcurl info message cache 10 (Closing connection 1654)
LogPlayLevel: Error: [2021.10.12-17.42.01:854][855]LogCesium: Error: [2021-10-12 13:42:01.854] [error] [Tile.cpp:404] An exception occurred while loading tile: Request failed.